the effect of luteal phase support on pregnancy rates of the stimulated intrauterine insemination cycles in couples with unexplained infertility
نویسندگان
چکیده
background: to assess the efficacy of luteal phase support (lps) with vaginal progesterone (p) on pregnancy rates of the stimulated intrauterine insemination (iui) cycles in couples with unexplained infertility (uei). materials and methods: this was a single-center, prospective, randomized, blinded control trial undertaken at a tertiary care university fertility center between october 2007 and december 2008. a total of 200 couples with uei underwent 511 consecutive stimulated iui cycles. clomiphene citrate (cc) and human menopausal gonadotropin (hmg) were used for ovulation induction. after iui, patients were randomized into two groups. the study group (n=98) received intra-vaginal p (cyclogest) for lps. the patients randomized into the control group (n=102) received no drug for lps. the main outcome was the comparison of clinical pregnancy rate (pr) and live birth rate (br) per cycle and patient between the control and study groups. results: there were no differences in demographic characteristics between the groups. pr per patient and cycle were similar in the study group (30.6% and 11.5%, respectively) and in the control group [25.5% and 10.03%, respectively] (p>0.05). there were no statistically significant increases in br per patient and cycle between the study group (19.4% and 7.5%, respectively) and the control group [14.7% and 5.7%, respectively] (p> 0.05). conclusion: administration of vaginal p (cyclogest) for lps does not improve the reproductive outcome of stimulated iui cycles (registeration number: irct1389 01283737n1).
منابع مشابه
The Effect of Luteal Phase Support on Pregnancy Rates of the Stimulated Intrauterine Insemination Cycles in Couples with Unexplained Infertility
Background To assess the efficacy of luteal phase support (LPS) with vaginal progesterone (P) on pregnancy rates of the stimulated intrauterine insemination (IUI) cycles in couples with unexplained infertility (UEI). MaterialsAndMethods This was a single-center, prospective, randomized, blinded control trial undertaken at a tertiary care university fertility center between October 2007 and Dece...
متن کاملEffect of Pertubation on Pregnancy Rates before Intrauterine Insemination Treatment in Patients with Unexplained Infertility
متن کامل
Luteal phase support in intrauterine insemination cycles
Intrauterine insemination (IUI) treatment aims to increase the rate of conception by increasing the chances that the maximum number of healthy sperm reach the site of fertilization. IUI with controlled ovarian stimulation is frequently used in assisted reproduction practice. Although widely used, the efficacy of luteal support in IUI remains controversial. In this article, we aimed to review wh...
متن کاملP-164: Comparision The Effect of GNRH Agonist Administration versus Vaginal Progesterone on Serum Progesterone in Luteal Phase in Ovarian Hyperstimulation and Intrauterine Insemination Cycles in Unexplained Infertility
Background: To compare the effect of GnRH agonist administration with vaginal progesterone on serum progesterone in Luteal phase in control ovarian hyper stimulation and intrauterine insemination cycles Materials and Methods: In this clinical trial, 242 infertile patients because of UEI (unexplained inferetility candidate for ovarian stimulation and intrauterine insemination reffering to infert...
متن کاملP-54: The Effect of Luteal Phase Support onPregnancy Rate of Stimulated IUI Cycles in UnexplaiendInfertility
Background: Progesterone (P) that is produced by the corpus luteum in response to stimulation by luteinizing hormone (LH) and human Chrionic Gondotropin (hCG) in luteal phase is essential for secretory transformation of endometrium that permits implantation .P not only supports endometrial development but also potentially sustains the survival of the embryo . Luteal phase dysfunction (LPD) is a...
متن کاملEffect of Pertubation on Pregnancy Rates before Intrauterine Insemination Treatment in Patients with Unexplained Infertility
BACKGROUND The aim of this study was to determine the relationship between marital violence and distress level among women with a diagnosis of infertility. MATERIALS AND METHODS In this prospective randomized study, a total of 180 patients were included in the study. Amongst these, pertubation of the uterine cavity was carried out in 79 patients prior to insemination. One patient in the pertu...
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عنوان ژورنال:
international journal of fertility and sterilityجلد ۴، شماره ۲، صفحات ۵۱-۵۶
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